I have divided up the ownership and use of each system into Feature areas. I am not going to make any category any more or less important than another, because what is important for me may not be important for you, and vice versa. It should give us an indication of how the setups generally stack up compared to the others, but each may have a deal-breaker for your particular application.
I have summarised all these features on the CheatSheet at the end of the article in the Conclusion.
So let's begin.
The Triplehead2Go setup is by far the messiest. You have to locate an extra box somewhere with two cables going to it from the PC, plus you have to be careful with the short dual-link DVI cable as Matrox stress that any damage or kinks can cause performance issues, as they run the cable to its maximum capability. You also lose a USB port to connect the Triplehead2Go box to the PC.
The Eyefinity setup is next, with an active adapter hanging off the Eyefinity card. My old style adapter is very messy and has a second cable to plug into the USB, although newer adapters appear not to need this. In general, the cabling is not as neat as the Nvidia Surround regardless of what adapter you use. The other issue with the new Eyefinity cards is that they are MASSIVE and they seem to keep growing. The HD6950 is even about 20% longer than my old HD5850. This presents a real problem in smaller cases, and even in my large case, required shuffling of hard drives to fit in. It's a pain.
The Nvidia Surround setup is clean. 3 DVI cables straight into the two DVI slots on the first card and first DVI slot on the second card. The cards are average in size, and fitting two into the case was Easy with a capital E.
This is something worth discussing straight away. Multi-monitor setups need VRAM, and lots of it. As much as possible, in fact. If you are planning on running a multi-monitor setup of any kind, get the most amount of VRAM you can afford.
In both systems, I bought the 2GB cards. Because the Nvidia Surround setup has two cards with 2GB VRAM, you may be inclined to think that the system has 4GB overall and therefore twice as much as the Eyefinity system, but it doesn't work like that. The cards are limited to the smallest VRAM of any card, as the data in memory needs to be mirrored across both cards, not spanned. So make sure you buy two cards the same, preferably with 2GB or higher.
In my test cases here, both systems have 2GB VRAM available to them, and so does the TH2G when it is connected to them.