I found sort of a fix. Like I mentioned earlier, I primarily play Source and Codemasters games. I found that if I disable AA in TF2, and enable it in the CCC my performance in Cross-Finity (EyeFire?) is greatly improved. I still get a little bit of stuttering, but this is worlds apart from where the stuttering was greatly affecting playability. Also this seems to be most important
ENABLE VSYNC IN CCC. This has been the biggest performance gain for me. Again I'm using two 5850 crossfired and eyefinitied so maybe this just works for me. Please don't be afraid to try though.
Right now I've got TF2 running 5760x1200 with 16x AA and 16x AF enabled through CCC - in game settings have AA disabled and Trilinear filtering.
GRID is running 5760x1200 with 4x AA and I'm shooting to get 8X AA enabled. Strangely it seems that you can't interrupt the opening animated sequence otherwise the loading screen grinds to slide show speeds.
I enabled AA (x4) in CCC and VSYNC also. My FPS do not appear to be much different, but, things do seem to be much smoother. Going to play more.
Thanks for the suggestions