Finally got the graphics horsepower to try out Crysis with TH2Go.
I set up system.cfg as mentioned. The game starts fine in 3840x1024... however I am unable to click on any option from the menu even though the mouse pointer is active; clicking does nothing.
Any thoughts?
Not sure I can help, but here's my two cents:
Using SoftTH instead of TH2Go, at first I could not click the mouse in the menu, but I could use the "arrow" keys to navigate the menus. Using the arrow keys I could load the game. I have since tweaked SoftTH's mouse settings, and now can use the mouse as well.