Set in the far flung future (the 37th century to be precise), THQ is billing Supreme Commander as the 'next evolution in RTS'. Supreme Commander has widely been referred to as the spiritual successor to Total Annihilation.
The game is focused on using a giant bipedal mech called an Armored Command Unit (or ACU) to build a base, then upgrading units to reach higher technology tiers, and conquering opponents. The player can command one of three nations: the Aeon Illuminate, the Cybran Nation, or the United Earth Federation.