I had the game preordered, and I completely finished the game in triplehead, no strange behavior of any sort, the only HUD in this game is the inventory screen, which is perfectly centered. Much like HL2, there are no cut scenes, everything is rendered in real time.
And I'm not sure what's wrong with his setup, I have a wimpy 5670 and I finished the game on medium to high settings at 40-60 FPS.
And this is not a source engine game, it's an in-house engine, HPL, I think.
And the demo is free, so if anyone has 1920 x 1080, please test it, I have no reason to think it wouldn't work though.
Is this game OpenGL only?
I bet it is, because there are ports for Linux and Mac.
The view angle on your 16:10 & multi-mon gameplay shots is identical, so how come the 4:3 shot is different ? ;)
You could also take screenies showing the hand cursor, and thus demonstrate the "HUD"'s behavior at the same time.
Regarding the 4:3 shot, I must have moved the mouse or something.