Yeah pretty much the same issue as LiquadSoap89...
Like you said Dopefish. If i turn the fixer on at the menu then yes it locks up pretty much as soon as the savegame loads, if i turn it on during gameplay (as per your suggestion) it will work for maybe 5-10-15 mins but it will eventually lock up...
Hope you find a work around, the game is so much better in Triple monitor, to the point im still playing it in triple monitor but with yucky stretch HUD.
Cheers
Also like to add that it locks up randomly, not just during cutscenes
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