I've been exploring other options, along the lines of what you suggested...
An update:
I went ahead and tested this. I'm not enamored with my current best solution; but, its somewhat workable.
Right now, to switch from my 3 monitor/UltraMon (business) setup to TH2Go (gaming), I have 4 steps.
1) Restart the machine
2) Choose "Game" hardware profile during startup
3) Change my active KVM port
4) Press "2" on the left-most monitor to change inputs.
It's possible to reconfigure this without restarting through the Windows Display Settings... I might be able to pull this off with a macro, though I'm sure it will wreak havoc on my desktop icons.
Anyway, I'm still hoping you've found something to make your reconfiguration easier; but, I wanted to say thank you again, it looks like you've helped me find a _tolerable_ solution, and I'll likely be keeping the TH2Go after all.