Alien Breed 2: Assault, like Evolution, is an isometric shooter set on board a futuristic spacecraft. In each level, the main character Conrad is given a series of tasks such as collecting key cards, restoring power, or escorting innocents, which he must complete before finding that level's exit. Standing in his way are a variety of aliens who will attack him, usually en masse. He can also suffer damage from explosions, fires, electrical disturbances, and enemy turrets. Conrad can run and shoot in all directions, and can collect a number of different weapons and items to aid him.