It might be a driver issue.
Q4 uses the same graphics engine as Doom 3 (works in 2560x1600 as well) so it should work just fine.
You are right it is a driver issue. the game works in 2560x1600 if use"High Quality" instead of "Ultra Quality". My "Ultra Quality" doesn't work at all in any resolutions. This has happened only after my using the 6.8 cats. With 6.5 "Ultra" worked fine. It's strange though as the 6.8 cats were suppossed to have the updated Open GL Quake 4 optimizations for improved performance. It could also be because of the new 1.03 patch though. Oh well. High quality is better than nothing I suppose.
Does anyone know how to make this monitor stretch out 2048x1536. It seems regardless of my driver settings the panel refuses to scale 2048x1536. It plays with ugly black borders. Is there any way to override this? also how can I make the colors in Tomb Raider legends better?